Some Nitrous Oxide References

Stacey et al (1992) Methionine in the treatment of nitrous oxide induced neuropathy and myeloneuropathy Journal of Neurology 239:401-403.
NIH Citation . Article PDF

   - 20 deaths.
   - 11 deaths, workplace misuse of nitrous.
   - 1 death, accidental asphyxia.
   - 2 deaths, asphyxia from gas masks covering the face.

FROM CHOCOLATE TO MORPHINE: Andrew Weil & Winifred Rosen. Make sure you
get the 1993 edition. It's the one with the horrible sub-title
"Everything You Need To Know About Mind-Altering Drugs". The sub-title's
wrong, but it's still a good reference.

A PRIMER OF DRUG ACTION: Robert M. Julien. I believe it's in the fifth
edition right now, but I don't know.

Pulsson (1979) "Recreational" misuse of nitrous oxide,
J. Am Dent. Soc. 98:410-411

Sahenk et al.(1978) "Polyneuropathy from inhalation of N2O cartridges
through a whipped cream dispenser" Neurology 28:485-487.

Annals of Internal Medicine, Vol 96, 3,Mar 1982, pp333-334:Home made Nitrous Oxide: No laughing matter.

Gillman, M.A. Nitrous oxide abuse in perspective
Clinical Neuropharmacol. 1992, 15:297-306

Dohrn, C.S., Lichtor, J.L., Finn, R.S., Uitvlugt, A., Coalson, D.W.,
Rupani, G., de Wit, H. and Zacny, J.P. Subjective and psychomotor
effects of nitrous oxide in healthy volunteers Behavioural Pharmacology

 1. Barker, George T.
      Instructions in the preparation, administration, and properties of
    nitrous oxide, protoxide of nitrogen, or laughing gas.  3rd ed.
    [Philadelphia] Rubencame and Barker, 1870.
        UCSF  Library   RD86.N7 B2 1870 Books

    Barton, William Paul Crillon, 1786-1856.
      A dissertation on the chymical properties and exhilerating effects of
    nitrous oxide gas; and its application to pneumatick medicine ...
    Philadelphia, Printed for the author, at the Lorenzo Press, 1808.
        UCD   HealthSci micro film 200 reel 6 no.144 Microform
        UCSF  Library   micro- film 658 History Media

 3. Bourne, James Gerald.
      Nitrous oxide in dentistry : its danger and alternatives / J. G. Bourne.
    Chicago : Year Book Publishers, 1960.
        UCSF  Library   RK512.N55 B67 1960 Books

 4. Davy, Humphry, Sir, 1778-1829.
      Researches, chemical and philosophical; chiefly concerning nitrous oxide,
    or dephlogisticated nitrous air, and its respiration, by Humphry Davy ...
    London, Printed for J. Johnson by Briggs and Cottle, 1800.
        UCLA  Biomed    WZ 260 D268r 1800 Rare Library has: Library's copy has
                        duplicate p.541-542 after p.580

 5. Eastwood, Douglas W.
      Nitrous oxide.  Philadelphia, F.A. Davis Co. [1964].
      Series title:  Clinical anesthesia 1/1964.
        UCD   HealthSci WO205 C65 1964 no.1
        UCSF  Library   RD81.A1 C64 v.1 1964 Books

 6. Nitrous oxide/N2O / edited by Edmond I. Eger II.  New York : Elsevier,
        UCD   HealthSci QV81 N58 1985
        UCI   Biomed    QV 81 N731 1985
        UCLA  Biomed    QV 81 N731 1985
        UCSD  Biomed    QV 81 N731 1985
        UCSF  Library   RD86.N7 N58 1985 Books
        CSL   Main Lib  RD86.N7 N58 1985 General Coll

 7. Shedlin, Michael.
      Laughing gas (nitrous oxide); historical and recent essays on the
    practice of inhaling nitrous oxide. Edited by Michael Shedlin & David
    Wallechinsky, with Saunie Salyer.  [1st ed.  n.p.] And/Or Press [1973].
        UCD   HealthSci QV81 S53
        UCSB  Main Lib  RD86.N7 S53 Sci-Eng

 8. Smith, W. D. A.
      Under the influence : a history of nitrous oxide and oxygen anaesthesia /
    W.D.A. Smith.  London : Scientific and Medical Division, Macmillan, 1982.
        UCD   HealthSci WO211.1 S65 1982
        UCI   Biomed    WO 211.1 S663u 1982
        UCLA  Biomed    WO 211.1 S663u 1982 Hist Div
        UCSD  Biomed    WO 211.1 S663u 1982
        UCSF  Library   RD79 .S65 1982 History

        Lancet, Vol.2 no.8102, 9 Dec. 1978, pg 1227-1230,
Myeloneuropathy after prolonged exposure to nitrous oxide.
        --the B12 deficiency. Doesn't look like a real problem without
very heavy use or very low B12 levels.

        Lancet, Aug12, 1978, pg339-342, Megaloblastic hemopoiesis in
patients receiving nitrous oxide.
        --B12 metabolism

        Anaesthesiology, 1978, Dec67(6) 960-964,
        --sorry, havn't got the title, this is about teratogenic effects
in rats.

        Anaesthesia, 34, 1979, pg147-151,
        --nitrous hazardous for patients with ear surgery or ear
disease. Forgot to mention this problem in the previous post. Does not
appear to be a problem if your ears are healthy.

        Seminars in Surgical Oncology, 1990, 6(3), 141-147
        --cancer, cause or cure? Havn't read this one (not in the local

        Abuse of volatile substances, information paper 2, (Australian)
Commonwealth Department of Health, Drugs of Dependency branch, 1984,
        --this is a great reference, a small booklet on N2O, patterns of
abuse, obtainability, toxicity and side effects, etc. Probably difficult
to get outside of Australia, but worth trying for.

        Acta Anae. Scand. 1985 29 pg 635-638,
        --study on volunteers looking at acute tolerance, subjective and
objective observations.

        Review of inhalants: Euphoria to Dysfuntion, Sharp, C.W. and
Brehm, M. L. (editors), NIDA research monograph no.15, U.S. Government
Printing Office, October 1977
        --this contains two articles, Abuse of Inhalation Anaesthetic
drugs, by M.B. Chenoweth, and Preclinical Behavioural toxicology of
Inhalant solvents, by R.E. Bowman, that are probably worthwhile.

        American Journal of Forensic Medical Pathology,
        1988, Mar 9(1), pg 60-63, Death by nitrous oxide: an interesting
case of auto-eroticism
        --sounds amusing.

        1989, Dec 10(4), pg 330-331,
        --another suicide case